Most of my heavy reading takes place in NetNewsWire, so I’ve coupled up Arc90’s Readability bookmarklet with the application.
It’s for use when you have to open up an item in the built-in browser. For full-text feeds, I recommend Cameron Hunt’s Bullit.
Instructions for using Readability with NetNewsWire:
Go to the Readability website. Choose your settings. Right-click on the ‘Readability’ [...]